Pesquisa | Secretaria de Estado da Saúde

1.

Accurate de novo design of membrane-traversing macrocycles.

Bhardwaj, Gaurav; O'Connor, Jacob; Rettie, Stephen; Huang, Yen-Hua; Ramelot, Theresa A; Mulligan, Vikram Khipple; Alpkilic, Gizem Gokce; Palmer, Jonathan; Bera, Asim K; Bick, Matthew J; Di Piazza, Maddalena; Li, Xinting; Hosseinzadeh, Parisa; Craven, Timothy W; Tejero, Roberto; Lauko, Anna; Choi, Ryan; Glynn, Calina; Dong, Linlin; Griffin, Robert; van Voorhis, Wesley C; Rodriguez, Jose; Stewart, Lance; Montelione, Gaetano T; Craik, David; Baker, David.

Cell ; 185(19): 3520-3532.e26, 2022 09 15.

Artigo Inglês | MEDLINE | ID: mdl-36041435

2.

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.

Walls, Alexandra C; Miranda, Marcos C; Schäfer, Alexandra; Pham, Minh N; Greaney, Allison; Arunachalam, Prabhu S; Navarro, Mary-Jane; Tortorici, M Alejandra; Rogers, Kenneth; O'Connor, Megan A; Shirreff, Lisa; Ferrell, Douglas E; Bowen, John; Brunette, Natalie; Kepl, Elizabeth; Zepeda, Samantha K; Starr, Tyler; Hsieh, Ching-Lin; Fiala, Brooke; Wrenn, Samuel; Pettie, Deleah; Sydeman, Claire; Sprouse, Kaitlin R; Johnson, Max; Blackstone, Alyssa; Ravichandran, Rashmi; Ogohara, Cassandra; Carter, Lauren; Tilles, Sasha W; Rappuoli, Rino; Leist, Sarah R; Martinez, David R; Clark, Matthew; Tisch, Roland; O'Hagan, Derek T; Van Der Most, Robbert; Van Voorhis, Wesley C; Corti, Davide; McLellan, Jason S; Kleanthous, Harry; Sheahan, Timothy P; Smith, Kelly D; Fuller, Deborah H; Villinger, Francois; Bloom, Jesse; Pulendran, Bali; Baric, Ralph S; King, Neil P; Veesler, David.

Cell ; 184(21): 5432-5447.e16, 2021 10 14.

Artigo Inglês | MEDLINE | ID: mdl-34619077

3.

An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii.

Sánchez-Sánchez, Roberto; Imhof, Dennis; Hecker, Yanina P; Ferre, Ignacio; Re, Michela; Moreno-Gonzalo, Javier; Blanco-Murcia, Javier; Mejías-López, Elena; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Ojo, Kayode K; Barrett, Lynn K; Hemphill, Andrew; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel.

J Infect Dis ; 229(2): 558-566, 2024 Feb 14.

Artigo Inglês | MEDLINE | ID: mdl-37889572

4.

Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells.

Ajiboye, Jubilee; Uldry, Anne-Christine; Heller, Manfred; Naguleswaran, Arunasalam; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew; Müller, Joachim.

Int J Mol Sci ; 25(5)2024 Feb 26.

Artigo Inglês | MEDLINE | ID: mdl-38473953

5.

Rapid Epidemic Expansion of Chikungunya Virus East/Central/South African Lineage, Paraguay.

Giovanetti, Marta; Vazquez, Cynthia; Lima, Mauricio; Castro, Emerson; Rojas, Analia; Gomez de la Fuente, Andrea; Aquino, Carolina; Cantero, Cesar; Fleitas, Fatima; Torales, Juan; Barrios, Julio; Ortega, Maria J; Gamarra, Maria L; Villalba, Shirley; Alfonzo, Tania; Xavier, Joilson; Adelino, Talita; Fritsch, Hegger; Iani, Felipe C M; Pereira, Glauco C; de Oliveira, Carla; Schuab, Gabriel; Rodrigues, Evandra S; Kashima, Simone; Leite, Juliana; Gresh, Lionel; Franco, Leticia; Tegally, Houriiyah; Van Voorhis, Wesley C; Lessels, Richard; de Filippis, Ana Maria Bispo; Ojeda, Andrea; Sequera, Guillermo; Montoya, Romeo; Holmes, Edward C; de Oliveira, Tulio; Rico, Jairo M; Lourenço, José; Fonseca, Vagner; Alcantara, Luiz C J.

Emerg Infect Dis ; 29(9): 1859-1863, 2023 09.

Artigo Inglês | MEDLINE | ID: mdl-37488810

6.

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.

Hulverson, Matthew A; Choi, Ryan; Schaefer, Deborah A; Betzer, Dana P; McCloskey, Molly C; Whitman, Grant R; Huang, Wenlin; Lee, Sangun; Pranata, Andy; McLeod, Malcolm D; Marsh, Kennan C; Kempf, Dale J; LeRoy, Bruce E; Zafiratos, Mark T; Bielinski, Aimee L; Hackman, Robert C; Ojo, Kayode K; Arnold, Samuel L M; Barrett, Lynn K; Tzipori, Saul; Riggs, Michael W; Fan, Erkang; Van Voorhis, Wesley C.

Antimicrob Agents Chemother ; 67(4): e0142522, 2023 04 18.

Artigo Inglês | MEDLINE | ID: mdl-36920244

7.

Appraisal of Fungus-Derived Xanthoquinodins as Broad-Spectrum Anti-Infectives Targeting Phylogenetically Diverse Human Pathogens.

Lee, Jin Woo; Collins, Jennifer E; Hulverson, Matthew A; Aguila, Laarni Kendra T; Kim, Caroline M; Wendt, Karen L; Chakrabarti, Debopam; Ojo, Kayode K; Wood, Gwendolyn E; Van Voorhis, Wesley C; Cichewicz, Robert H.

J Nat Prod ; 86(6): 1596-1605, 2023 06 23.

Artigo Inglês | MEDLINE | ID: mdl-37276438

8.

Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice.

Schlange, Carling; Müller, Joachim; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Boubaker, Ghalia; Ortega-Mora, Luis-Miguel; Wong, Ho Ning; Haynes, Richard K; Van Voorhis, Wesley C; Hemphill, Andrew.

Exp Parasitol ; 255: 108655, 2023 Dec.

Artigo Inglês | MEDLINE | ID: mdl-37981259

9.

Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.

Zhang, Cindy X; Love, Melissa S; McNamara, Case W; Chi, Victor; Woods, Ashley K; Joseph, Sean; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Iroh Tam, Pui-Ying; Van Voorhis, Wesley C; Arnold, Samuel L M.

Antimicrob Agents Chemother ; 66(1): e0156021, 2022 01 18.

Artigo Inglês | MEDLINE | ID: mdl-34748385

10.

Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio.

Müller, Joachim; Anghel, Nicoleta; Imhof, Dennis; Hänggeli, Kai; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Ortega-Mora, Luis-Miguel; Van Voorhis, Wesley C; Hemphill, Andrew.

Int J Mol Sci ; 23(4)2022 Feb 21.

Artigo Inglês | MEDLINE | ID: mdl-35216497

11.

Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults.

Healy, Sara A; Murphy, Sean C; Hume, Jen C C; Shelton, Lisa; Kuntz, Steve; Van Voorhis, Wesley C; Moodie, Zoe; Metch, Barbara; Wang, Ruobing; Silver-Brace, Tiffany; Fishbaugher, Matthew; Kennedy, Mark; Finney, Olivia C; Chaturvedi, Richa; Marcsisin, Sean R; Hobbs, Charlotte V; Warner-Lubin, Margaret; Talley, Angela K; Wong-Madden, Sharon; Stuart, Ken; Wald, Anna; Kappe, Stefan H; Kublin, James G; Duffy, Patrick E.

Clin Infect Dis ; 71(6): 1481-1490, 2020 09 12.

Artigo Inglês | MEDLINE | ID: mdl-31621832

12.

Taming the Boys for Global Good: Contraceptive Strategy to Stop Malaria Transmission.

Choi, Ryan; Michaels, Samantha A; Onu, Emmanuel C; Hulverson, Matthew A; Saha, Aparajita; Coker, Morenike E; Weeks, Janis C; Van Voorhis, Wesley C; Ojo, Kayode K.

Molecules ; 25(12)2020 Jun 16.

Artigo Inglês | MEDLINE | ID: mdl-32560085

13.

P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.

Arnold, Samuel L M; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Mccloskey, Molly C; Dorr, Carlie S; Vidadala, Rama S R; Khatod, Mansi; Morada, Mary; Barrett, Lynn K; Maly, Dustin J; Yarlett, Nigel; Van Voorhis, Wesley C.

J Infect Dis ; 220(7): 1188-1198, 2019 08 30.

Artigo Inglês | MEDLINE | ID: mdl-31180118

14.

Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.

Hulverson, Matthew A; Bruzual, Igor; McConnell, Erin V; Huang, Wenlin; Vidadala, Rama S R; Choi, Ryan; Arnold, Samuel L M; Whitman, Grant R; McCloskey, Molly C; Barrett, Lynn K; Rivas, Kasey L; Scheele, Suzanne; DeRocher, Amy E; Parsons, Marilyn; Ojo, Kayode K; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Doggett, J Stone.

J Infect Dis ; 219(9): 1464-1473, 2019 04 16.

Artigo Inglês | MEDLINE | ID: mdl-30423128

15.

Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.

Sánchez-Sánchez, Roberto; Ferre, Ignacio; Re, Michela; Ramos, Juan José; Regidor-Cerrillo, Javier; Pizarro Díaz, Manuel; González-Huecas, Marta; Tabanera, Enrique; Benavides, Julio; Hemphill, Andrew; Hulverson, Matthew A; Barrett, Lynn K; Choi, Ryan; Whitman, Grant R; Ojo, Kayode K; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel.

Antimicrob Agents Chemother ; 63(7)2019 07.

Artigo Inglês | MEDLINE | ID: mdl-31061151

16.

Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase.

Milanes, Jillian E; Suryadi, Jimmy; Abendroth, Jan; Van Voorhis, Wesley C; Barrett, Kayleigh F; Dranow, David M; Phan, Isabelle Q; Patrick, Stephen L; Rozema, Soren D; Khalifa, Muhammad M; Golden, Jennifer E; Morris, James C.

Antimicrob Agents Chemother ; 63(5)2019 05.

Artigo Inglês | MEDLINE | ID: mdl-30783001

17.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.

Buckner, Frederick S; Ranade, Ranae M; Gillespie, J Robert; Shibata, Sayaka; Hulverson, Matthew A; Zhang, Zhongsheng; Huang, Wenlin; Choi, Ryan; Verlinde, Christophe L M J; Hol, Wim G J; Ochida, Atsuko; Akao, Yuichiro; Choy, Robert K M; Van Voorhis, Wesley C; Arnold, Sam L M; Jumani, Rajiv S; Huston, Christopher D; Fan, Erkang.

Antimicrob Agents Chemother ; 63(4)2019 04.

Artigo Inglês | MEDLINE | ID: mdl-30745384

18.

Susceptibility Testing of Medically Important Parasites.

Genetu Bayih, Abebe; Debnath, Anjan; Mitre, Edward; Huston, Christopher D; Laleu, Benoît; Leroy, Didier; Blasco, Benjamin; Campo, Brice; Wells, Timothy N C; Willis, Paul A; Sjö, Peter; Van Voorhis, Wesley C; Pillai, Dylan R.

Clin Microbiol Rev ; 30(3): 647-669, 2017 07.

Artigo Inglês | MEDLINE | ID: mdl-28446445

19.

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.

Scheele, Suzanne; Geiger, Jennifer A; DeRocher, Amy E; Choi, Ryan; Smith, Tess R; Hulverson, Matthew A; Vidadala, Rama Subba Rao; Barrett, Lynn K; Maly, Dustin J; Merritt, Ethan A; Ojo, Kayode K; Van Voorhis, Wesley C; Parsons, Marilyn.

Antimicrob Agents Chemother ; 62(6)2018 06.

Artigo Inglês | MEDLINE | ID: mdl-29555627

20.

Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.

Lee, Sangun; Ginese, Melanie; Beamer, Gillian; Danz, Hillary R; Girouard, Donald J; Chapman-Bonofiglio, Susan P; Lee, Minhee; Hulverson, Matthew A; Choi, Ryan; Whitman, Grant R; Ojo, Kayode K; Arnold, Samuel L M; Van Voorhis, Wesley C; Tzipori, Saul.

Antimicrob Agents Chemother ; 62(7)2018 07.

Artigo Inglês | MEDLINE | ID: mdl-29661877

Secretaria de Estado da Saúde - BVS

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